Once known as the “King Coal Highway”, this corridor has been a crucial source of energy in the United States by providing secure and reliable resources. Significant and widespread changes within the national and global economies present weighty challenges for the regions’ people, businesses, and governments. However, this change can also help transform regional economic outcomes for decades to come by adeptly applying technological innovation and efficiencies. These efforts must be complementary and supportive of successful industries in West Virginia (tourism and recreation, transportation and logistics, etc.) rather than an independent effort moving away from them entirely.